Taking a look at the 1990 Capcom shmup '1941 Counter attack'. This game was originally released on the CPS-1 system that is very similar to the Megadrive, Genesis, AtariST, Amiga, Neogeo range of systems that were out there back in the day.
The combo motorola 68000 and zilog Z80 is found in a lot of the systems back in the day.